Noonautics and the Trace Institute announced a research collaboration to build a mathematical framework for the human DMT experience. Noonautics, led by neurobiologist Dr. Andrew Gallimore, will use the extended state DMTx protocol, developed with Dr. Rick Strassman, to extend DMT experiences from minutes to hours so trained observers can make sustained observations from inside the state. The Trace Institute, led by Professor Emeritus Donald Hoffman, will apply trace logic and conscious realism, an observer-centered model of reality, to give the resulting phenomenology a quantitative structure.
I commented on HHS-OASH-2026-0232-0001, the Request for Information regarding the proposed 7-hydroxymitragynine (7-OH) scheduling threshold.
Comment Tracking Number: mry-8nrd-tg5g
I am submitting this comment in response to the Request for Information regarding the proposed 7-hydroxymitragynine (7-OH) scheduling threshold (Docket HHS-OASH-2026-0232).
First, on the imminent-hazard finding itself: temporary scheduling under 21 U.S.C. 811(h)(1) is meant to address genuinely urgent threats that cannot wait for ordinary scheduling procedure. I would ask OASH to specify the comparative risk data—overdose rate, dependence liability, and ER visits per capita of users—that establishes 7-OH at the proposed threshold as more hazardous than legal, widely available substances such as alcohol, which carries well-documented acute toxicity and tens of thousands of attributable deaths annually without triggering emergency scheduling. Absent that comparative showing, it is difficult to evaluate whether the proposed threshold reflects an evidentiary emergency finding or a policy preference.
Most cannabis formulations, built around just THC and CBD, can work for intimacy—but they require a certain amount of mental effort to stay in a good headspace. That’s the kind of effort you don’t need to be making.
Adding a third cannabinoid—CBN (cannabinol)—to the THC+CBD combination creates something noticeably more stable. In a 1:1:1 ratio of Δ9-THC, CBD, and CBN, the experience is self-regulating. You don’t need to steer your mood. The blend handles that, freeing your attention for your partner, your body, and the moment.
I recently tried 5-MAPB (5-(2-methylaminopropyl)benzofuran) at 80mg on a single occasion—my first experience with an MDMA-like compound. This gave me a useful point of comparison with psilomethoxin (Pm).
In my judgment, Pm at 0.5–1g most closely resembles 5-MAPB. Below that range, Pm is too subtle; above it, the experience pulls inward too firmly in a way that diverges from the 5-MAPB character.
The comparison confirmed differences I had suspected. 5-MAPB is a stimulant—sleep on the day of administration was a challenge. Pm is not a stimulant; as noted in the original case report, falling asleep at the peak is possible.
Drug regulation should not be a criminal matter, but addressed by health care providers. I urge the DEA to drop this attempt to schedule more substances.
Personal Liberty: At the heart of the decriminalization movement lies the principle of individual autonomy. Adults should have the right to choose what they put into their own bodies, as long as their actions don’t harm others. Criminalizing personal drug use infringes on this fundamental freedom, treating individuals as criminals for making private choices.
Using this function, you can estimate the effect of multiple capsules taken at different times. For example, suppose you take 2 at 10am, 1 at 10:45am, 1 at 11:15am, and 1 at 11:45am. If you space out 5 capsules like this then the peak is only about 3.5 capsules worth at 1pm:
July 30, 2026
